VU0467154

VU0467154 is a small molecule. It is provided as a yellow powder.

Allosteric activators of the M4 muscarinic acetylcholine receptor represent a novel approach for the treatment of psychotic symptoms associated with schizophrenia and other neuropsychiatric disorders. VU0467154 produced a robust dose-dependent reversal of MK-801-induced hyperlocomotion and deficits in preclinical models of associative learning and memory functions in wild-type mice, but failed to reverse these stimulant-induced deficits in M4 KO mice. VU0467154 also enhanced the acquisition of both contextual and cue-mediated fear conditioning when administered alone in wild-type mice.

Target	VU0467154
Form	Solid
Purity	> 98% (HPLC). Conforms to structure by NMR.
Reconstitution	Soluble in DMSO.
Storage	Store desiccated at -20 °C for up to 1 year. Solutions can be stored at -20 °C for up to 3 months.
Molecular Weight	444.4 g/mol
Molecular Formula	C17H15F3N4O3S2
Buffer	Not applicable.
CAS Number	1451993-15-9
SMILES	O=S(C1=CC=C(C=C1)CNC(C2=C(N)C 3=C(C)C(C)=NN=C3S2)=O)(C(F)(F)F)= O
Availability	Shipped within 5-12 working days.
Note	THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.

Research Articles on VU0467154

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