2'-5'-Oligoadenylate Synthetase 1 (OAS1) Antibody

2'-5'-Oligoadenylate Synthetase 1 (OAS1) Antibody is a Rabbit Polyclonal antibody for the detection of OAS1.

Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L.

Target	2'-5'-Oligoadenylate Synthetase 1 (OAS1)
Clonality	Polyclonal
Reactivity	Human, Rat
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	2',5'-oligoadenylate synthetase 1, 40/46kDa
Isotype	IgG
Form	Liquid
Purity	≥ 95% (SDS-PAGE)
Purification	Purified by immunogen affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Validity	12 months.
UniProt Primary AC	P00973 (UniProt, ExPASy)
UniProt Entry Name	OAS1_HUMAN
Gene Symbol	OAS1
GeneID	4938
KEGG	hsa:4938
String	9606.ENSP00000388001
Molecular Weight	Observed MW: 48 kDa
Buffer	PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Concentration	2 mg/ml
Availability	Shipped within 5-12 working days.
Note	This product is for research use only.

Research Articles on 2'-5'-Oligoadenylate Synthetase 1 (OAS1)

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