Cyclin-Dependent Kinase Inhibitor P27 (27Kip1) Antibody
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Catalogue No: abx032765
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US$326.25
(Size: 80 µl)
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Datasheet SDS
p27Kip1 is a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.
Research Articles on Cyclin-Dependent Kinase Inhibitor P27 (27Kip1)
| Target | Cyclin-Dependent Kinase Inhibitor P27 (27Kip1) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IF/ICC: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 165-194 amino acids from the C-terminal region of human 27Kip1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P46527 (UniProt, ExPASy) |
| UniProt Secondary AC | Q16307, Q5U0H2, Q9BUS6 |
| UniProt Entry Name | CDN1B_HUMAN |
| KEGG | hsa:1027 |
| String | 9606.ENSP00000228872 |
| Molecular Weight | Calculated MW: 22.1 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Hamster CDKN1B. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |