3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) Antibody
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Catalogue No: abx216539
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US$420.50
(Size: 100 µg)
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Datasheet SDS
3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) Antibody is a Rabbit Polyclonal antibody for the detection of HMGCR. HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Research Articles on 3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR)
| Target | 3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) |
| Research Area | Enzymes and Kinases |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, IHC |
| Host | Rabbit |
| Recommended dilutions | IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | 3-hydroxy-3-methylglutaryl-Coenzyme A reductase |
| Isotype | IgG |
| Form | Liquid |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P04035 (UniProt, ExPASy) |
| UniProt Secondary AC | B7Z3Y9, Q8N190 |
| UniProt Entry Name | HMDH_HUMAN |
| Gene Symbol | HMGCR |
| GeneID | 3156 |
| OMIM | 142910 |
| HGNC | 5006 |
| KEGG | hsa:3156 |
| Ensembl | ENSG00000113161 |
| String | 9606.ENSP00000287936 |
| Molecular Weight | Observed MW: 120 kDa |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |