Broad Substrate Specificity ATP-Binding Cassette Transporter ABCG2 (ABCG2) Antibody
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Catalogue No: abx028408
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US$326.25
(Size: 80 µl)
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Datasheet SDS
ABCG2 is a membrane-associated protein included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue.
Research Articles on Broad Substrate Specificity ATP-Binding Cassette Transporter ABCG2 (ABCG2)
| Target | Broad Substrate Specificity ATP-Binding Cassette Transporter ABCG2 (ABCG2) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB, IHC, FCM |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/100 - 1/500, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide from the C-terminal region of Human ABCG2 (594-623 AA). |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by saturated ammonium sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q9UNQ0 (UniProt, ExPASy) |
| UniProt Entry Name | ABCG2_HUMAN |
| NCBI Accession | NP_001244315.1 NP_004818.2 |
| String | 9606.ENSP00000237612 |
| Molecular Weight | Calculated MW: 72.3 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |