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Tyrosine-Protein Kinase ABL1 (ABL1) Antibody

Catalogue No: abx000665
Price: £95.00
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Tyrosine-Protein Kinase ABL1 (ABL1) Antibody Tyrosine-Protein Kinase ABL1 (ABL1) Antibody

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ABL1 Antibody is a Rabbit Polyclonal antibody against ABL1. This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons.

Target ABL1
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB, IHC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Synthetic peptide. C term -peptide of human ABL1.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UNSPSC Code 12352203
UniProt Primary AC P00519
Gene Symbol ABL1
GeneID 25
OMIM 189980
HGNC 76
Ensembl ENSG00000097007
Molecular Weight Calculated MW: 122 kDa, 124 kDa
Observed MW: 139 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Tyrosine-Protein Kinase ABL1 (ABL1) Antibody

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