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ABL1 (pY245) Antibody

Catalogue No: abx000091
Price: £120.00
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ABL1 (pY245) Antibody

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ABL1 (pY245) Antibody is a Rabbit Polyclonal antibody against ABL1 (pY245). The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11.

Target ABL1 (pY245)
Clonality Polyclonal
Reactivity Human, Mouse
Tested Applications WB, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Synthetic Peptide. A phospho specific peptide corresponding to residues surrounding Y245 of human ABL1.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P00519 (UniProt, ExPASy)
UniProt Secondary AC A3KFJ3, Q13869, Q13870, Q16133, Q17R61, Q45F09
UniProt Entry Name ABL1_HUMAN
Gene Symbol ABL1
GeneID 25
OMIM 189980
HGNC 76
KEGG hsa:25
Ensembl ENSG00000097007
String 9606.ENSP00000361423
Molecular Weight Calculated MW: 122 kDa, 124 kDa
Observed MW: Refer to Figures
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on ABL1 (pY245) Antibody

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