Acetyl Coenzyme A Carboxylase Alpha (ACACA) Antibody

Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene.

Target	Acetyl Coenzyme A Carboxylase Alpha (ACACA)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 2010-2039 amino acids from the C-terminal region of human ACACA.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q13085 (UniProt, ExPASy)
UniProt Entry Name	ACACA_HUMAN
KEGG	hsa:31
String	9606.ENSP00000483300
Molecular Weight	Calculated MW: 266 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse, Rat, Cow and Sheep ACACA.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Acetyl Coenzyme A Carboxylase Alpha (ACACA)

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