Angiotensin Converting Enzyme 2 (ACE2) Antibody

Catalogue No: abx032686
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Angiotensin Converting Enzyme 2 (ACE2) Antibody Angiotensin Converting Enzyme 2 (ACE2) Antibody Angiotensin Converting Enzyme 2 (ACE2) Antibody

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ACE2 cDNA encodes a deduced 805-amino acid protein containing a potential 17-amino acid N-terminal signal peptide and a putative 22-amino acid C-terminal membrane anchor. It also possesses a zinc metalloprotease consensus sequence and a conserved glutamine residue that may function as a third zinc ligand. ACE2 is expressed predominantly in vascular endothelial cells of the heart and kidney. ACE converts angiotensin I to angiotensin II, ACE2 converts angiotensin I to angiotensin 1-9, which has 9 amino acids. Angiotensin II is a potent blood vessel constrictor, while angiotensin 1-9 does not impact blood vessels but is cleaved by ACE to a shorter peptide, angiotensin 1-7, which is a blood vessel dilator. Spike (S) proteins of coronaviruses, including the SARS coronavirus, bind with cellular receptors to mediate infection of target cells. ACE2 binds the S1 domain of the SARS coronavirus S protein. SARS coronavirus replicates efficiently on ACE2-transfected but not mock-transfected 293T cells. Anti-ACE2 but not anti-ACE1 antibody blocks viral replication on Vero E6 cells. It has been proposed that ACE2 is a functional receptor for SARS coronavirus.

Target Angiotensin Converting Enzyme 2 (ACE2)
Clonality Polyclonal
Reactivity Human
Tested Applications ELISA, WB, IHC, FCM
Host Rabbit
Recommended dilutions WB: 1/1000, IHC-P: 1/50 - 1/100, FCM: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen KLH-conjugated synthetic peptide between 140-172 amino acids from the Central region of human ACE2 (SARS Receptor).
Isotype IgG
Purification Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q9BYF1 (UniProt, ExPASy)
UniProt Secondary AC C7ECU1, Q6UWP0, Q86WT0, Q9NRA7, Q9UFZ6
UniProt Entry Name ACE2_HUMAN
Gene Symbol ACE2
GeneID 59272
NCBI Accession NP_068576.1
String 9606.ENSP00000389326
Buffer PBS containing 0.09% sodium azide.
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Angiotensin Converting Enzyme 2 (ACE2) Antibody

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