ACK1 (pY826) Antibody

ACK1 is a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP) stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway.

Target	ACK1 (pY826)
Clonality	Polyclonal
Target Modification	Tyr826
Modification	Phosphorylation
Reactivity	Human
Tested Applications	ELISA, DB
Host	Rabbit
Recommended dilutions	DB: 1/500. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y826 of human ACK1.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by two-step phosphospecific peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q07912 (UniProt, ExPASy)
UniProt Secondary AC	Q6ZMQ0, Q8N6U7, Q96H59
UniProt Entry Name	ACK1_HUMAN
KEGG	hsa:10188
String	9606.ENSP00000371341
Molecular Weight	Calculated MW: 115 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse, Rat and Cow TNK2.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on ACK1 (pY826)

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