Cytoplasmic Aconitate Hydratase (ACO1) Antibody
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Catalogue No: abx004618
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US$217.50
(Size: 20 µl)
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Datasheet SDS
ACO1 Antibody is a Rabbit Monoclonal antibody against ACO1. The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants.
Research Articles on Cytoplasmic Aconitate Hydratase (ACO1)
| Target | Cytoplasmic Aconitate Hydratase (ACO1) |
| Research Area | Enzymes and Kinases |
| Clonality | Monoclonal |
| Reactivity | Mouse, Rat |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Synthetic peptide corresponding to ACO1. The exact sequence is proprietary. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P21399 (UniProt, ExPASy) |
| UniProt Secondary AC | D3DRK7, Q14652, Q5VZA7 |
| UniProt Entry Name | ACOC_HUMAN |
| Gene Symbol | ACO1 |
| GeneID | 48 |
| KEGG | hsa:48 |
| String | 9606.ENSP00000309477 |
| Enzyme Commission Number | EC 4.2.1.3 EC 4.2.1 |
| Molecular Weight | Calculated MW: 98 kDa Observed MW: 100 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |