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Alpha Actinin 1 (ACTN1) Antibody
Catalogue No: abx001074
Price:
£120.00
(Size: 20 µl)
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ACTN1 Antibody is a Rabbit Polyclonal antibody against ACTN1. Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene.
Research Articles on ACTN1
| Target | ACTN1 |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Monkey |
| Tested Applications | WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant protein of human ACTN1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P12814 (UniProt, ExPASy) |
| UniProt Secondary AC | B3V8S3, B4DHH3, B7TY16, Q1HE25, Q9BTN1 |
| UniProt Entry Name | ACTN1_HUMAN |
| Gene Symbol | ACTN1 |
| GeneID | 87 |
| KEGG | hsa:87 |
| String | 9606.ENSP00000377941 |
| Molecular Weight | Calculated MW: 102 kDa, 103 kDa, 105 kDa, 107 kDa Observed MW: 110 kDa |
| Buffer | PBS, pH 7.3, 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.5 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |
