Alpha Actinin 1 (ACTN1) Antibody

Catalogue No: abx001074
Price: £120.00
(Size: 20 µl)
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ACTN1 Antibody is a Rabbit Polyclonal antibody against ACTN1. Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene.

Target ACTN1
Clonality Polyclonal
Reactivity Human, Mouse, Monkey
Tested Applications WB, IHC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human ACTN1.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P12814 (UniProt, ExPASy)
UniProt Secondary AC B3V8S3, B4DHH3, B7TY16, Q1HE25, Q9BTN1
UniProt Entry Name ACTN1_HUMAN
Gene Symbol ACTN1
GeneID 87
KEGG hsa:87
String 9606.ENSP00000377941
Molecular Weight Calculated MW: 102 kDa, 103 kDa, 105 kDa, 107 kDa
Observed MW: 110 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 0.5 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on ACTN1

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