Activin A Receptor Type 1C (ACVR1C) Antibody

Catalogue No: abx000813
Price: £120.00
(Size: 20 µl)

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Datasheet SDS
ACVR1C Antibody is a Rabbit Polyclonal antibody against ACVR1C. ACTR-IC (Activin receptor type 1C), also referred to as Activin receptor-like kinase 7 (ALK-7), is a type I serine/threonine kinase receptor. ACTA-IC contains an extracellular binding domain, an intracellular serine/threonine kinase domain preceded by a GS box and a transmembrane domain. It is expressed throughout the digestive and central nervous system and localizes to the cell surface. Four ACTR-IC transcripts are generated by alternative splicing. Transcript 1 is the functional full length receptor, transcript 2 lacks a complete receptor binding domain and transcripts 3 and 4 are soluble proteins that lack a transmembrane domain. ACTR-IC is a receptor for Activin AB, Activin B and Nodal. In pancreatic cells, ACTR-IC forms a complex with Activin receptor type IIB (ACTR-IIB). The kinase domain of ACTR-IC can induce Smad2 and Smad3 signalling pathways. In some cell lines, ACTR-IC overexpression induces apoptosis and inhibits proliferation.

Target Activin A Receptor Type 1C (ACVR1C)
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB, IHC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human ACVR1C.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q8NER5 (UniProt, ExPASy)
UniProt Secondary AC Q4ZFZ8, Q86UL1, Q86UL2, Q8TBG2
UniProt Entry Name ACV1C_HUMAN
Gene Symbol ACVR1C
GeneID 130399
KEGG hsa:130399
String 9606.ENSP00000243349
Molecular Weight Calculated MW: 37 kDa, 46 kDa, 49 kDa, 54 kDa
Observed MW: 60 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 0.5 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Activin A Receptor Type 1C (ACVR1C)

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