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ACVR1C Antibody is a Rabbit Polyclonal antibody against ACVR1C. ACTR-IC (Activin receptor type 1C), also referred to as Activin receptor-like kinase 7 (ALK-7), is a type I serine/threonine kinase receptor. ACTA-IC contains an extracellular binding domain, an intracellular serine/threonine kinase domain preceded by a GS box and a transmembrane domain. It is expressed throughout the digestive and central nervous system and localizes to the cell surface. Four ACTR-IC transcripts are generated by alternative splicing. Transcript 1 is the functional full length receptor, transcript 2 lacks a complete receptor binding domain and transcripts 3 and 4 are soluble proteins that lack a transmembrane domain. ACTR-IC is a receptor for Activin AB, Activin B and Nodal. In pancreatic cells, ACTR-IC forms a complex with Activin receptor type IIB (ACTR-IIB). The kinase domain of ACTR-IC can induce Smad2 and Smad3 signalling pathways. In some cell lines, ACTR-IC overexpression induces apoptosis and inhibits proliferation.
| Target |
Activin A Receptor Type 1C (ACVR1C) |
| Clonality |
Polyclonal |
| Reactivity |
Human, Mouse, Rat |
| Tested Applications |
WB, IHC |
| Host |
Rabbit |
| Recommended dilutions |
WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation |
Unconjugated |
| Immunogen |
Recombinant protein of human ACVR1C. |
| Isotype |
IgG |
| Form |
Liquid |
| Purification |
Affinity purified. |
| Storage |
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC |
Q8NER5 (UniProt,
ExPASy)
|
| UniProt Secondary AC |
Q4ZFZ8, Q86UL1, Q86UL2, Q8TBG2 |
| UniProt Entry Name |
ACV1C_HUMAN |
| Gene Symbol |
ACVR1C |
| GeneID |
130399
|
| KEGG |
hsa:13039
|
| String |
9606.ENSP00000243349
|
| Molecular Weight |
Calculated MW: 37 kDa, 46 kDa, 49 kDa, 54 kDa
Observed MW: 60 kDa |
| Buffer |
PBS, pH 7.3, 0.02% sodium azide, 50% glycerol. |
| Concentration |
> 1 mg/ml |
| Availability |
Shipped within 5-10 working days. |
| Note |
This product is for research use only. |
Research Articles on Activin A Receptor Type 1C (ACVR1C) Antibody
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