Disintegrin And Metalloproteinase Domain-Containing Protein 17 (ADAM 17) Antibody

Disintegrin And Metalloproteinase Domain-Containing Protein 17 (ADAM 17) Antibody is a Rabbit Polyclonal antibody for the detection of ADAM17.

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates, including cell adhesion proteins, cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands. The encoded protein also plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of this gene has been observed in specific cell types derived from psoriasis, rheumatoid arthritis, multiple sclerosis and Crohn's disease patients, suggesting that the encoded protein may play a role in autoimmune disease.

Target	Disintegrin And Metalloproteinase Domain-Containing Protein 17 (ADAM 17)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	ADAM metallopeptidase domain 17
Isotype	IgG
Form	Liquid
Purity	≥ 95% (SDS-PAGE)
Purification	Purified by immunogen affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Validity	12 months.
UniProt Primary AC	P78536 (UniProt, ExPASy)
UniProt Secondary AC	O60226
UniProt Entry Name	ADA17_HUMAN
Gene Symbol	ADAM17
GeneID	6868
OMIM	603639
HGNC	195
KEGG	hsa:6868
Ensembl	ENSG00000151694
String	9606.ENSP00000309968
Enzyme Commission Number	EC 3.4.24.86
Molecular Weight	Observed MW: 115 kDa
Buffer	PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Concentration	2 mg/ml
Availability	Shipped within 5-12 working days.
Note	This product is for research use only.

Research Articles on Disintegrin And Metalloproteinase Domain-Containing Protein 17 (ADAM 17)

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