ADAM Metallopeptidase Domain 17 (ADAM17) Antibody

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Catalogue No: abx000869
Price: US$203.00
(Size: 20 µl)

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Datasheet SDS
ADAM17 Antibody is a Rabbit Polyclonal antibody against ADAM17. The ADAMs (A Disintegrin And Metalloprotease) are multidomain transmembrane proteins. One of the first ADAMs implicated in membrane shedding is ADAM-17, which is shown to release the active form of tumor necrosis factor (TNF)-a from its precursor(PMID:18238782). ADAM17 is also named as CSVP, TACE. The full length protein has 9 glycosylation sites, a signal peptide, propeptide and 2 isoforms produced by alternative splicing.The 120-kDa form of ADAM-17 is expressed more frequently and at higher levels in primary breast carcinomas compared with normal breast tissue(PMID:17438092). This antibody is specific to ADAM17.

Target ADAM Metallopeptidase Domain 17 (ADAM17)
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB, IHC, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/1000, IHC-P: 1/100 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen A synthetic peptide corresponding to a sequence within amino acids 700-824 of human ADAM17.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P78536 (UniProt, ExPASy)
UniProt Secondary AC O60226
UniProt Entry Name ADA17_HUMAN
Gene Symbol ADAM17
GeneID 6868
NCBI Accession NP_003174.3
KEGG hsa:6868
String 9606.ENSP00000309968
Molecular Weight Calculated MW: 93 kDa
Observed MW: 120/100 kDa
Buffer PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration > 0.2 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on ADAM Metallopeptidase Domain 17 (ADAM17)


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