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ADAM Metallopeptidase With Thrombospondin Type 1 Motif 4 (ADAMTS4) Antibody

Catalogue No: abx001965
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ADAM Metallopeptidase With Thrombospondin Type 1 Motif 4 (ADAMTS4) Antibody

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ADAMTS4 Antibody is a Rabbit Polyclonal antibody against ADAMTS4. This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma.

Target ADAMTS4
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human ADAMTS4.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC O75173 (UniProt, ExPASy)
UniProt Secondary AC Q2HYD0, Q5VTW2, Q6P4Q8, Q6UWA8, Q9UN83
UniProt Entry Name ATS4_HUMAN
Gene Symbol ADAMTS4
GeneID 9507
KEGG hsa:9507
String 9606.ENSP00000356975
Molecular Weight Calculated MW: 90 kDa
Observed MW: 90 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on ADAM Metallopeptidase With Thrombospondin Type 1 Motif 4 (ADAMTS4) Antibody

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