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ADAM Metallopeptidase With Thrombospondin Type 1 Motif 4 (ADAMTS4) Antibody
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Catalogue No: abx001965
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US$348.00
(Size: 60 µl)
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Datasheet SDS
ADAMTS4 Antibody is a Rabbit Polyclonal antibody against ADAMTS4. This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma.
Research Articles on ADAM Metallopeptidase With Thrombospondin Type 1 Motif 4 (ADAMTS4)
| Target | ADAM Metallopeptidase With Thrombospondin Type 1 Motif 4 (ADAMTS4) |
| Research Area | Enzymes and Kinases, Tumor Immunity, Infection Immunity, Neuroscience, Rheumatology, Cancer |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | IF/ICC |
| Host | Rabbit |
| Recommended dilutions | IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein corresponding to human ADAMTS4 |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | O75173 (UniProt, ExPASy) |
| UniProt Secondary AC | Q2HYD0, Q5VTW2, Q6P4Q8, Q6UWA8, Q9UN83 |
| UniProt Entry Name | ATS4_HUMAN |
| Gene Symbol | ADAMTS4 |
| GeneID | 9507 |
| NCBI Accession | NP_005090.3 |
| KEGG | hsa:9507 |
| String | 9606.ENSP00000356975 |
| Molecular Weight | Calculated MW: 90 kDa Observed MW: 90 kDa |
| Buffer | PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
