Adrenergic Receptor Beta Kinase 1 (ADRBK1) Antibody

Beta-adrenergic receptor kinase (ADRBK1), also known as GRK2, phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. ADRBK1 is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Heart failure is accompanied by severely impaired beta-adrenergic receptor (beta-AR) function. An important mechanism for the rapid desensitization of beta-AR function is agonist-stimulated receptor phosphorylation by the beta-AR kinase (beta-ARK1), an enzyme known to be elevated in failing human heart tissue. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.

Target	Adrenergic Receptor Beta Kinase 1 (ADRBK1)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 633-660 amino acids from the C-terminal region of human ADRBK1.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P25098 (UniProt, ExPASy)
UniProt Secondary AC	B0ZBE1, Q13837, Q6GTT3
UniProt Entry Name	ARBK1_HUMAN
NCBI Accession	NP_001610.2
KEGG	hsa:156
String	9606.ENSP00000312262
Molecular Weight	Calculated MW: 79.6 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse, Rat and Cow GRK2.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Adrenergic Receptor Beta Kinase 1 (ADRBK1)

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