Adrenergic Receptor Beta Kinase 1 (ADRBK1) Antibody

ADRBK1 Antibody is a Rabbit Polyclonal antibody against ADRBK1. The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.

Target	Adrenergic Receptor Beta Kinase 1 (ADRBK1)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 440-689 of human GRK2.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P25098 (UniProt, ExPASy)
UniProt Secondary AC	B0ZBE1, Q13837, Q6GTT3
UniProt Entry Name	ARBK1_HUMAN
Gene Symbol	GRK2
GeneID	156
NCBI Accession	NP_001610.2
KEGG	hsa:156
String	9606.ENSP00000312262
Molecular Weight	Calculated MW: 80 kDa Observed MW: 80 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Adrenergic Receptor Beta Kinase 1 (ADRBK1)

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