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This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. This antibody is supplied as crude ascites.
Target |
Alpha-Fetoprotein (AFP) |
Clonality |
Monoclonal |
Reactivity |
Human |
Tested Applications |
ELISA, WB |
Host |
Mouse |
Recommended dilutions |
WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
Conjugation |
Unconjugated |
Immunogen |
KLH-conjugated synthetic peptide between 56-85 amino acids from human AFP. |
Isotype |
IgM |
Form |
Liquid |
Purification |
Unpurified crude ascites. |
Storage |
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
UniProt Primary AC |
P02771 (UniProt,
ExPASy)
|
UniProt Secondary AC |
B2RBU3 |
UniProt Entry Name |
FETA_HUMAN |
KEGG |
hsa:174
|
String |
9606.ENSP00000379138
|
Molecular Weight |
Calculated MW: 68.7 kDa |
Buffer |
Ascites containing 0.09% sodium azide. |
Availability |
Please enquire. |
Note |
This product is for research use only. |
Research Articles on Alpha-Fetoprotein (AFP)