Advanced Glycosylation End Product Specific Receptor (AGER) Antibody
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Catalogue No: abx230209
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US$420.50
(Size: 100 µg)
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Datasheet SDS
Advanced Glycosylation End Product Specific Receptor (AGER) Antibody is a Rabbit polyclonal against Advanced Glycosylation End Product Specific Receptor (AGER). AGER mediates interactions of advanced glycosylation end products (AGE), non-enzymatically glycosylated proteins that accumulate in vascular tissue in aging and at an accelerated rate in diabetes. AGER is a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. It interacts with S100A12 on endothelium, mononuclear phagocytes and lymphocytes, triggers cellular activation and generates important proinflammatory mediators. It is a receptor for amyloid beta peptide and facilitates its translocation across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP asa complex with RAGE to the intraneuronal space. AGER also binds oligonucleotides.
Research Articles on Advanced Glycosylation End Product Specific Receptor (AGER)
| Target | Advanced Glycosylation End Product Specific Receptor (AGER) |
| Research Area | Metabolic Pathways, Tumor Immunity, Endocrinology, Cardiovascular Biology, Neuroscience, Cancer |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/200 - 1/2000, IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Advanced Glycosylation End Product Specific Receptor (AGER) |
| Isotype | IgG |
| Form | Liquid |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q15109 (UniProt, ExPASy) |
| UniProt Entry Name | RAGE_HUMAN |
| KEGG | hsa:177 |
| String | 9606.ENSP00000364210 |
| Molecular Weight | Observed MW: 43 kDa |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |