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Apoptosis Inducing Factor 1, Mitochondrial (AIFM1) Antibody
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Catalogue No: abx002005
Price:
US$493.00
(Size: 120 µl)
Orders to United States ship from United States
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AIFM1 Antibody is a Rabbit Polyclonal antibody against AIFM1. This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6, which results in a severe mitochondrial encephalomyopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10.
Research Articles on Apoptosis Inducing Factor 1, Mitochondrial (AIFM1)
| Target | Apoptosis Inducing Factor 1, Mitochondrial (AIFM1) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB, IHC, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/20 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein corresponding to human AIF |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | O95831 (UniProt, ExPASy) |
| UniProt Entry Name | AIFM1_HUMAN |
| Gene Symbol | AIFM1 |
| GeneID | 9131 |
| NCBI Accession | NP_004199.1 |
| KEGG | hsa:9131 |
| String | 9606.ENSP00000287295 |
| Molecular Weight | Calculated MW: 26 kDa/28 kDa/35 kDa/66 kDa Observed MW: 60 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
