Apoptosis Inducing Factor 1, Mitochondrial (AIFM1) Antibody

Catalogue No: abx002005
Price: £160.00
(Size: 20 µl)
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AIFM1 Antibody is a Rabbit Polyclonal antibody against AIFM1. This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6, which results in a severe mitochondrial encephalomyopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10.

Target AIFM1
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB, IHC, IF/ICC, IP
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IHC: 1/50 - 1/200, IF/ICC: 1/50 - 1/200, IP: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human AIFM1.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC O95831 (UniProt, ExPASy)
UniProt Entry Name AIFM1_HUMAN
Gene Symbol AIFM1
GeneID 9131
KEGG hsa:9131
String 9606.ENSP00000287295
Molecular Weight Calculated MW: 26 kDa, 28 kDa, 35 kDa, 66 kDa
Observed MW: 67 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 0.5 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on AIFM1

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