AKT Interacting Protein (AKTIP) Antibody

The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB) /Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein.

Target	AKT Interacting Protein (AKTIP)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 262-288 amino acids from the C-terminal region of human AKTIP.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q9H8T0 (UniProt, ExPASy)
UniProt Secondary AC	Q503B1, Q53H38
UniProt Entry Name	AKTIP_HUMAN
Gene Symbol	AKTIP
String	9606.ENSP00000378152
Molecular Weight	Calculated MW: 33.1 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse, Rat, Chicken and Monkey AKTIP.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on AKT Interacting Protein (AKTIP)

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