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Aldehyde Dehydrogenase, Mitochondrial (ALDH2) Antibody
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Catalogue No: abx001138
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US$217.50
(Size: 20 µl)
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Datasheet SDS
ALDH2 Antibody is a Rabbit Polyclonal antibody against ALDH2. Acetaldehyde dehydrogenase is the next enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism. It mediates NADP+-dependent oxidation of aldehydes into acids during detoxification of alcohol-derived acetaldehyde; lipid peroxidation; and metabolism of corticosteroids, biogenic amines and neurotransmitters. Genetic variation in ALDH2 is responsible for individual differences in responses to drinking alcohol. Thus, the absence of this enzyme is linked to alcohol intolerance and a reduced risk for alcoholism-related liver disease.
Research Articles on Aldehyde Dehydrogenase, Mitochondrial (ALDH2)
| Target | Aldehyde Dehydrogenase, Mitochondrial (ALDH2) |
| Research Area | Enzymes and Kinases, Metabolism, Hepatology |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 321-480 of human ALDH2. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P05091 (UniProt, ExPASy) |
| UniProt Secondary AC | B4DW54, E7EUE5, Q03639, Q6IB13, Q6IV71 |
| UniProt Entry Name | ALDH2_HUMAN |
| Gene Symbol | ALDH2 |
| GeneID | 217 |
| NCBI Accession | NP_000681.2 |
| KEGG | hsa:217 |
| String | 9606.ENSP00000261733 |
| Molecular Weight | Calculated MW: 56 kDa Observed MW: 50-56 kDa |
| Buffer | PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol. |
| Concentration | 7.93 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |