Methylmalonate-Semialdehyde Dehydrogenase [acylating], Mitochondrial (ALDH6A1) Antibody

ALDH6A1 Antibody is a Rabbit Polyclonal antibody against ALDH6A1. This gene encodes a member of the aldehyde dehydrogenase protein family. The encoded protein is a mitochondrial methylmalonate semialdehyde dehydrogenase that plays a role in the valine and pyrimidine catabolic pathways. This protein catalyzes the irreversible oxidative decarboxylation of malonate and methylmalonate semialdehydes to acetyl- and propionyl-CoA. Methylmalonate semialdehyde dehydrogenase deficiency is characterized by elevated beta-alanine, 3-hydroxypropionic acid, and both isomers of 3-amino and 3-hydroxyisobutyric acids in urine organic acids. Alternate splicing results in multiple transcript variants.

Target	Methylmalonate-Semialdehyde Dehydrogenase [acylating], Mitochondrial (ALDH6A1)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 326-535 of human ALDH6A1.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q02252 (UniProt, ExPASy)
UniProt Secondary AC	B2R609, B4DFS8, J3KNU8, Q9UKM8
UniProt Entry Name	MMSA_HUMAN
Gene Symbol	ALDH6A1
GeneID	4329
NCBI Accession	NP_005580.1
KEGG	hsa:4329
String	9606.ENSP00000450436
Molecular Weight	Calculated MW: 58 kDa Observed MW: 58 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Methylmalonate-Semialdehyde Dehydrogenase [acylating], Mitochondrial (ALDH6A1)

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