Programmed Cell Death 6-Interacting Protein (PDCD6IP) Antibody

ALIX Antibody is a Rabbit Polyclonal antibody against ALIX. This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15.

Target	Programmed Cell Death 6-Interacting Protein (PDCD6IP)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/200 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human ALIX / PDCD6IP.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q8WUM4 (UniProt, ExPASy)
UniProt Secondary AC	C5MQH7, E9PFU1, Q6NUS1, Q9BX86, Q9NUN0, Q9P2H2, Q9UKL5
UniProt Entry Name	PDC6I_HUMAN
Gene Symbol	PDCD6IP
GeneID	10015
OMIM	608074
NCBI Accession	NP_037506.2
HGNC	8766
KEGG	hsa:10015
Ensembl	ENSG00000170248
String	9606.ENSP00000411825
Molecular Weight	Calculated MW: 96 kDa Observed MW: 105 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	3.76 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Programmed Cell Death 6-Interacting Protein (PDCD6IP)

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