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ALG-2-Interacting Protein X (PDCD6IP) Antibody

Catalogue No: abx001822
Price: £120.00
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ALG-2-Interacting Protein X (PDCD6IP) Antibody ALG-2-Interacting Protein X (PDCD6IP) Antibody ALG-2-Interacting Protein X (PDCD6IP) Antibody ALG-2-Interacting Protein X (PDCD6IP) Antibody

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ALIX Antibody is a Rabbit Polyclonal antibody against ALIX. This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15.

Target ALIX / PDCD6IP
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB, IHC
Host Rabbit
Recommended dilutions WB: 1/200 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human ALIX / PDCD6IP.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q8WUM4 (UniProt, ExPASy)
UniProt Secondary AC C5MQH7, E9PFU1, Q6NUS1, Q9BX86, Q9NUN0, Q9P2H2, Q9UKL5
UniProt Entry Name PDC6I_HUMAN
Gene Symbol PDCD6IP
GeneID 10015
KEGG hsa:10015
String 9606.ENSP00000411825
Molecular Weight Calculated MW: 30 kDa, 96 kDa
Observed MW: 109 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration 3.76 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on ALG-2-Interacting Protein X (PDCD6IP) Antibody

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