Polyunsaturated Fatty Acid 5-Lipoxygenase (ALOX5) Antibody
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Catalogue No: abx001770
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US$348.00
(Size: 60 µl)
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Datasheet SDS
ALOX5 Antibody is a Rabbit Polyclonal antibody against ALOX5. This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Research Articles on Polyunsaturated Fatty Acid 5-Lipoxygenase (ALOX5)
| Target | Polyunsaturated Fatty Acid 5-Lipoxygenase (ALOX5) |
| Research Area | Enzymes and Kinases, Metabolic Pathways, Tumor Immunity, Cardiovascular Biology, Neuroscience, Cancer |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | IHC, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein corresponding to human ALOX5 |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P09917 (UniProt, ExPASy) |
| UniProt Secondary AC | B7ZLS0, E5FPY5, E5FPY7, E5FPY8, Q5JQ14 |
| UniProt Entry Name | LOX5_HUMAN |
| Gene Symbol | ALOX5 |
| GeneID | 240 |
| NCBI Accession | NP_000689.1 |
| KEGG | hsa:240 |
| String | 9606.ENSP00000363512 |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
