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Polyunsaturated Fatty Acid 5-Lipoxygenase (ALOX5) Antibody

Catalogue No: abx001770
Price: £120.00
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Polyunsaturated Fatty Acid 5-Lipoxygenase (ALOX5) Antibody Polyunsaturated Fatty Acid 5-Lipoxygenase (ALOX5) Antibody

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ALOX5 Antibody is a Rabbit Polyclonal antibody against ALOX5. This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Target Polyunsaturated Fatty Acid 5-Lipoxygenase (ALOX5)
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB, IHC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human ALOX5.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P09917 (UniProt, ExPASy)
UniProt Secondary AC B7ZLS0, E5FPY5, E5FPY7, E5FPY8, Q5JQ14
UniProt Entry Name LOX5_HUMAN
Gene Symbol ALOX5
GeneID 240
KEGG hsa:240
String 9606.ENSP00000363512
Molecular Weight Calculated MW: 56 kDa, 61 kDa, 71 kDa, 74 kDa, 77 kDa
Observed MW: 68 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Polyunsaturated Fatty Acid 5-Lipoxygenase (ALOX5) Antibody

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