Alpha Synuclein Phospho-Ser129 (SNCA pS129) Antibody (ATTO488)

Alpha Synuclein Phospho-Ser129 (SNCA pS129) Antibody (ATTO488) is a rabbit monoclonal antibody against Alpha Synuclein Phospho-Ser129 (SNCA pS129). Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016].

Target	Alpha Synuclein Phospho-Ser129 (SNCA pS129)
Clonality	Monoclonal
Target Modification	Ser129
Modification	Phosphorylation
Reactivity	Human, Mouse
Tested Applications	ELISA, WB, IHC, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	ATTO488
Immunogen	Human alpha synuclein AA 124-134: AYEMP-pS-EEGYQ-Cys.
Isotype	IgG
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P37840 (UniProt, ExPASy)
UniProt Secondary AC	A8K2A4, Q13701, Q4JHI3, Q6IAU6
UniProt Entry Name	SYUA_HUMAN
Gene Symbol	SNCA
GeneID	6622
OMIM	163890
NCBI Accession	NP_000336.1
HGNC	11138
KEGG	hsa:6622
String	9606.ENSP00000338345
Buffer	PBS, pH 7.4, 50% glycerol, 0.09% sodium azide.
Specificity	Binds to phosphorylated serine 129 on alpha synuclein. Does not detect unphosphorylated serine 129 alpha synuclein.
Concentration	1 mg/ml
Availability	Shipped within 5-12 working days.
Note	This product is for research use only.

Research Articles on Alpha Synuclein Phospho-Ser129 (SNCA pS129)

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