Alpha Synuclein Phospho-Ser129 (SNCA pS129) Antibody (ATTO594)
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Catalogue No: abx451873
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(Size: 100 µg)
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Alpha Synuclein Phospho-Ser129 (SNCA pS129) Antibody (ATTO594) is a rabbit monoclonal antibody against Alpha Synuclein Phospho-Ser129 (SNCA pS129). Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016].
Research Articles on Alpha Synuclein Phospho-Ser129 (SNCA pS129)
| Target | Alpha Synuclein Phospho-Ser129 (SNCA pS129) |
| Clonality | Monoclonal |
| Target Modification | Ser129 |
| Modification | Phosphorylation |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | ATTO594 |
| Immunogen | Human alpha synuclein AA 124-134: AYEMP-pS-EEGYQ-Cys. |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at 4°C. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P37840 (UniProt, ExPASy) |
| UniProt Secondary AC | A8K2A4, Q13701, Q4JHI3, Q6IAU6 |
| UniProt Entry Name | SYUA_HUMAN |
| Gene Symbol | SNCA |
| GeneID | 6622 |
| OMIM | 163890 |
| NCBI Accession | NP_000336.1 |
| HGNC | 11138 |
| KEGG | hsa:6622 |
| String | 9606.ENSP00000338345 |
| Buffer | PBS, pH 7.4, 50% glycerol, 0.09% sodium azide. |
| Specificity | Binds to phosphorylated serine 129 on alpha synuclein. Does not detect unphosphorylated serine 129 alpha synuclein. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |