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Alpha Synuclein (SNCA) Antibody
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Catalogue No: abx239916
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US$420.50
(Size: 100 µg)
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Datasheet SDS
Alpha Synuclein (SNCA) Antibody is a Mouse Monoclonal antibody for the detection of alpha-synuclein. Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene.
Research Articles on Alpha Synuclein (SNCA)
| Target | Alpha Synuclein (SNCA) |
| Clonality | Monoclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB, IHC |
| Host | Mouse |
| Recommended dilutions | WB: 1/500 - 1/2000, IHC: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | synuclein, alpha (non A4 component of amyloid precursor) |
| Isotype | IgG1 |
| Form | Liquid |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by Protein A and Protein G affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P37840 (UniProt, ExPASy) |
| UniProt Secondary AC | A8K2A4, Q13701, Q4JHI3, Q6IAU6 |
| Gene Symbol | SNCA |
| GeneID | 6622 |
| OMIM | 127750 |
| HGNC | 11138 |
| Ensembl | ENSG00000145335 |
| Molecular Weight | Observed MW: 18 kDa |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |