Activating Molecule In BECN1-Regulated Autophagy Protein 1 (AMBRA1) Antibody

AMBRA1 Antibody is a Rabbit Polyclonal antibody against AMBRA1. WD-repeats are motifs that are found in a variety of proteins and are characterized by a conserved core of 40-60 amino acids that commonly form a tertiary propeller structure. While proteins that contain WD-repeats participate in a wide range of cellular functions, they are generally involved in regulatory mechanisms concerning chromatin assembly, cell cycle control, signal transduction, RNA processing, apoptosis and vesicular trafficking. AMBRA1 (Activating molecule in BECN1-regulated autophagy protein 1), also known as WDR94 or KIAA1736, is a 1,298 amino acid protein that contains three WD repeats. Localized to cytoplasmic vesicles, AMBRA1 functions to control protein turnover, cell proliferation and cell survival during neuronal development, thereby playing an important role in autophagy and the development of the nervous system. Multiple isoforms of AMBRA1 exist due to alternative spicing events.

Target	Activating Molecule In BECN1-Regulated Autophagy Protein 1 (AMBRA1)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IHC, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 1109-1208 of human Ambra1.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q9C0C7 (UniProt, ExPASy)
UniProt Secondary AC	A6XN33, D3DQP8, G3V193, Q86XD6, Q9H8Z0, Q9NXE7
UniProt Entry Name	AMRA1_HUMAN
Gene Symbol	AMBRA1
GeneID	55626
NCBI Accession	NP_060219.2
String	9606.ENSP00000431926
Molecular Weight	Calculated MW: 143 kDa Observed MW: 130-150 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Activating Molecule In BECN1-Regulated Autophagy Protein 1 (AMBRA1)

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