Activating Molecule In BECN1-Regulated Autophagy Protein 1 (AMBRA1) Antibody
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Catalogue No: abx001006
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US$217.50
(Size: 20 µl)
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Datasheet SDS
AMBRA1 Antibody is a Rabbit Polyclonal antibody against AMBRA1. WD-repeats are motifs that are found in a variety of proteins and are characterized by a conserved core of 40-60 amino acids that commonly form a tertiary propeller structure. While proteins that contain WD-repeats participate in a wide range of cellular functions, they are generally involved in regulatory mechanisms concerning chromatin assembly, cell cycle control, signal transduction, RNA processing, apoptosis and vesicular trafficking. AMBRA1 (Activating molecule in BECN1-regulated autophagy protein 1), also known as WDR94 or KIAA1736, is a 1,298 amino acid protein that contains three WD repeats. Localized to cytoplasmic vesicles, AMBRA1 functions to control protein turnover, cell proliferation and cell survival during neuronal development, thereby playing an important role in autophagy and the development of the nervous system. Multiple isoforms of AMBRA1 exist due to alternative spicing events.
Research Articles on Activating Molecule In BECN1-Regulated Autophagy Protein 1 (AMBRA1)
| Target | Activating Molecule In BECN1-Regulated Autophagy Protein 1 (AMBRA1) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant protein corresponding to AMBRA1. The exact sequence is proprietary. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q9C0C7 (UniProt, ExPASy) |
| UniProt Secondary AC | A6XN33, D3DQP8, G3V193, Q86XD6, Q9H8Z0, Q9NXE7 |
| UniProt Entry Name | AMRA1_HUMAN |
| Gene Symbol | AMBRA1 |
| GeneID | 55626 |
| NCBI Accession | NP_060219.2 |
| String | 9606.ENSP00000431926 |
| Molecular Weight | Calculated MW: 143 kDa Observed MW: 130-150 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |