Activating Molecule In BECN1-Regulated Autophagy Protein 1 (AMBRA1) Antibody

Catalogue No: abx001006
Price: £120.00
(Size: 20 µl)
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AMBRA1 Antibody is a Rabbit Polyclonal antibody against AMBRA1. WD-repeats are motifs that are found in a variety of proteins and are characterized by a conserved core of 40-60 amino acids that commonly form a tertiary propeller structure. While proteins that contain WD-repeats participate in a wide range of cellular functions, they are generally involved in regulatory mechanisms concerning chromatin assembly, cell cycle control, signal transduction, RNA processing, apoptosis and vesicular trafficking. AMBRA1 (Activating molecule in BECN1-regulated autophagy protein 1), also known as WDR94 or KIAA1736, is a 1,298 amino acid protein that contains three WD repeats. Localized to cytoplasmic vesicles, AMBRA1 functions to control protein turnover, cell proliferation and cell survival during neuronal development, thereby playing an important role in autophagy and the development of the nervous system. Multiple isoforms of AMBRA1 exist due to alternative spicing events.

Target AMBRA1
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB, IHC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human AMBRA1.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q9C0C7 (UniProt, ExPASy)
UniProt Secondary AC A6XN33, D3DQP8, G3V193, Q86XD6, Q9H8Z0, Q9NXE7
UniProt Entry Name AMRA1_HUMAN
Gene Symbol AMBRA1
GeneID 55626
String 9606.ENSP00000431926
Molecular Weight Calculated MW: 84 kDa, 132 kDa, 135 kDa, 139 kDa, 142 kDa
Observed MW: 140 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 0.5 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on AMBRA1

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