5'-AMP-Activated Protein Kinase Catalytic Subunit Alpha-1 (PRKAA1) Antibody
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Catalogue No: abx033226
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US$326.25
(Size: 80 µl)
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Datasheet SDS
AMPK is responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. It appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. PRKAA11, a member of the Ser/Thr protein kinase family, is a catalytic subunit of AMPK.
Research Articles on 5'-AMP-Activated Protein Kinase Catalytic Subunit Alpha-1 (AMPK alpha 1)
| Target | 5'-AMP-Activated Protein Kinase Catalytic Subunit Alpha-1 (AMPK alpha 1) |
| Research Area | Enzymes and Kinases, Metabolism |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/8000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 479-510 amino acids from the C-terminal region of human AMPK alpha 1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q13131 (UniProt, ExPASy) |
| UniProt Secondary AC | A8MTQ6, B2R7E1, O00286, Q5D0E1, Q86VS1, Q9UNQ4 |
| UniProt Entry Name | AAPK1_HUMAN |
| KEGG | hsa:5562 |
| String | 9606.ENSP00000346148 |
| Molecular Weight | Calculated MW: 64 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |