Amyloid-Beta A4 Precursor Protein-Binding Family B Member 1 (APBB1) Antibody
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Catalogue No: abx001587
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US$217.50
(Size: 20 µl)
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Datasheet SDS
APBB1 Antibody is a Rabbit Polyclonal antibody against APBB1. The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Research Articles on Amyloid-Beta A4 Precursor Protein-Binding Family B Member 1 (APBB1)
| Target | Amyloid-Beta A4 Precursor Protein-Binding Family B Member 1 (APBB1) |
| Research Area | Neuroscience |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, WB: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 359-708 of human APBB1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | O00213 (UniProt, ExPASy) |
| UniProt Entry Name | APBB1_HUMAN |
| Gene Symbol | APBB1 |
| GeneID | 322 |
| NCBI Accession | NP_663722.1 |
| KEGG | hsa:322 |
| String | 9606.ENSP00000477213 |
| Molecular Weight | Calculated MW: 77 kDa Observed MW: 63 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |