DNA-(Apurinic Or Apyrimidinic Site) Lyase (APEX1) Antibody

APEX1 Antibody is a Rabbit Polyclonal antibody against APEX1. Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein.

Target	DNA-(Apurinic Or Apyrimidinic Site) Lyase (APEX1)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	WB, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 1-318 of human APEX1/APE1.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P27695 (UniProt, ExPASy)
UniProt Secondary AC	Q969L5, Q99775
UniProt Entry Name	APEX1_HUMAN
Gene Symbol	APEX1
GeneID	318
NCBI Accession	NP_542380.1
KEGG	hsa:328
String	9606.ENSP00000216714
Molecular Weight	Calculated MW: 36 kDa Observed MW: 39 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on DNA-(Apurinic Or Apyrimidinic Site) Lyase (APEX1)

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