Apolipoprotein E (APOE) Antibody

Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.

Target	Apolipoprotein E (APOE)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 263-292 amino acids from the C-terminal region of human APOE.
Isotype	IgG
Form	Liquid
Purification	Purified Rabbit Polyclonal Antibody.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P02649 (UniProt, ExPASy)
UniProt Secondary AC	B2RC15, C0JYY5, Q9P2S4
UniProt Entry Name	APOE_HUMAN
NCBI Accession	NP_000032.1
KEGG	hsa:348
String	9606.ENSP00000252486
Molecular Weight	Calculated MW: 36.2 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Monkey APOE.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Apolipoprotein E (APOE)

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