Apoptosis Protease Activating Factor 1 (APAF1) Antibody
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Catalogue No: abx000846
Price:
US$348.00
(Size: 60 µl)
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Datasheet SDS
APAF1 Antibody is a Rabbit Polyclonal antibody against APAF1. This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Research Articles on Apoptosis Protease Activating Factor 1 (APAF1)
| Target | Apoptosis Protease Activating Factor 1 (APAF1) |
| Research Area | Apoptosis |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein corresponding to human APAF1 |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | O14727 (UniProt, ExPASy) |
| GeneID | 317 |
| NCBI Accession | NP_863651.1 |
| Molecular Weight | Calculated MW: 37 kDa/133 kDa/135 kDa/137 kDa/140 kDa/141 kDa Observed MW: 142 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
