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Amyloid-beta Precursor Protein Phospho-Thr743 (APP pT743) Antibody
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Catalogue No: abx000096
Price:
US$232.00
(Size: 20 µl)
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APP (pT743) Antibody is a Rabbit Polyclonal antibody against APP (pT743). This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.
Research Articles on Amyloid-beta Precursor Protein Phospho-Thr743 (APP pT743)
| Target | Amyloid-beta Precursor Protein Phospho-Thr743 (APP pT743) |
| Clonality | Polyclonal |
| Reactivity | Mouse, Rat |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Synthetic peptide corresponding to APP pT743. The exact sequence is proprietary. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P05067 (UniProt, ExPASy) |
| Gene Symbol | APP |
| GeneID | 4609 |
| NCBI Accession | NP_958817.1 |
| Molecular Weight | Calculated MW: 87 kDa Observed MW: 87 kDa |
| Buffer | PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |