Low Density Lipoprotein Receptor Adapter Protein 1 (LDLRAP1) Antibody

LDLRAP1 is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. The PTD domain has been found to interact with the cytoplasmic tail of the LDL receptor. This adapter protein is required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). LDLRAP1 may be required for LDL binding and internalization but not for receptor clustering in coated pits. This protein may facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits, and may also be involved in the internalization of other LDLR family members. Mutations in the LDLRAP1 gene lead to LDL receptor malfunction and cause the disorder autosomal recessive hypercholesterolaemia.

Target	Low Density Lipoprotein Receptor Adapter Protein 1 (LDLRAP1)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 11-42 amino acids from the N-terminal region of human ARH (LDLRAP1).
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q5SW96 (UniProt, ExPASy)
UniProt Secondary AC	A2BHI5, Q6TQS9, Q8N2Y0, Q9UFI9
UniProt Entry Name	ARH_HUMAN
KEGG	hsa:26119
String	9606.ENSP00000363458
Molecular Weight	Calculated MW: 33.9 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse and Rat LDLRAP1.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Low Density Lipoprotein Receptor Adapter Protein 1 (LDLRAP1)

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