Low Density Lipoprotein Receptor Adapter Protein 1 (LDLRAP1) Antibody
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Catalogue No: abx033819
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US$326.25
(Size: 80 µl)
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Datasheet SDS
LDLRAP1 is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. The PTD domain has been found to interact with the cytoplasmic tail of the LDL receptor. This adapter protein is required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). LDLRAP1 may be required for LDL binding and internalization but not for receptor clustering in coated pits. This protein may facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits, and may also be involved in the internalization of other LDLR family members. Mutations in the LDLRAP1 gene lead to LDL receptor malfunction and cause the disorder autosomal recessive hypercholesterolaemia.
Research Articles on Low Density Lipoprotein Receptor Adapter Protein 1 (LDLRAP1)
| Target | Low Density Lipoprotein Receptor Adapter Protein 1 (LDLRAP1) |
| Research Area | Metabolism |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 277-306 amino acids from the C-terminal region of human ARH (LDLRAP1). |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q5SW96 (UniProt, ExPASy) |
| UniProt Secondary AC | A2BHI5, Q6TQS9, Q8N2Y0, Q9UFI9 |
| UniProt Entry Name | ARH_HUMAN |
| KEGG | hsa:26119 |
| String | 9606.ENSP00000363458 |
| Molecular Weight | Calculated MW: 33.9 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |