Arrestin Beta 1 (ARRB1) Antibody

Members of ARRB1/beta-ARRB1 protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. ARRB1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-ARRB1 system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of ARRB1 have been described, however, their exact functions are not known.

Target	Arrestin Beta 1 (ARRB1)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC, IF/ICC, FCM
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/10 - 1/50, IF/ICC: 1/10 - 1/50, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 336-363 amino acids from the C-terminal region of human ARRB1.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P49407 (UniProt, ExPASy)
UniProt Secondary AC	B6V9G8, O75625, O75630, Q2PP20, Q9BTK8
UniProt Entry Name	ARRB1_HUMAN
KEGG	hsa:408
String	9606.ENSP00000409581
Molecular Weight	Calculated MW: 47.1 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse, Rat, Cow and Rabbit ARRB1.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Arrestin Beta 1 (ARRB1)

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