Arrestin Beta 2 (ARRB2) Antibody

ARRB2 Antibody is a Rabbit Polyclonal antibody against ARRB2. Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. ARRB2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for ARRB2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Target	Arrestin Beta 2 (ARRB2)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IHC, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic peptide corresponding to a sequence within amino acids 300-400 of human ARRB2.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P32121 (UniProt, ExPASy)
UniProt Entry Name	ARRB2_HUMAN
Gene Symbol	ARRB2
GeneID	409
OMIM	107941
NCBI Accession	NP_004304.1
HGNC	712
KEGG	hsa:409
Ensembl	ENSG00000141480
String	9606.ENSP00000403701
Molecular Weight	Calculated MW: 46 kDa Observed MW: 46 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Arrestin Beta 2 (ARRB2)

Write a review

Your Name

Your Email Address

PMID

DOI

Your Review

Rating

Continue