Apoptosis Signal Regulating Kinase 1 (ASK1) Antibody

This product is currently in development. The lead time for this product may be several months. Please contact us at [email protected] for an updated lead time before purchasing this product.

Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1, 374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK) /stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK.

Target	Apoptosis Signal Regulating Kinase 1 (ASK1)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/100 - 1/500. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 61-90 amino acids from human ASK1 (MEKK5/MAP3K5).
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q99683 (UniProt, ExPASy)
UniProt Secondary AC	A6NIA0, B4DGB2, Q5THN3, Q99461
UniProt Entry Name	M3K5_HUMAN
Gene Symbol	MAP3K5
KEGG	hsa:4217
String	9606.ENSP00000351908
Molecular Weight	Calculated MW: 155 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Please enquire.
Note	This product is for research use only.

Research Articles on Apoptosis Signal Regulating Kinase 1 (ASK1)

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