Argininosuccinate Lyase (ASL) Antibody

ASL Antibody is a Rabbit Polyclonal antibody against ASL. This gene encodes a member of the lyase 1 family. The encoded protein forms a cytosolic homotetramer and primarily catalyzes the reversible hydrolytic cleavage of argininosuccinate into arginine and fumarate, an essential step in the liver in detoxifying ammonia via the urea cycle. Mutations in this gene result in the autosomal recessive disorder argininosuccinic aciduria, or argininosuccinic acid lyase deficiency. A nontranscribed pseudogene is also located on the long arm of chromosome 22. Alternatively spliced transcript variants encoding different isoforms have been described.

Target	Argininosuccinate Lyase (ASL)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IHC, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 289-464 of human ASL.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P04424 (UniProt, ExPASy)
UniProt Secondary AC	E7EMI0, E9PE48, Q6LDS5, Q96HS2
UniProt Entry Name	ARLY_HUMAN
Gene Symbol	ASL
GeneID	435
NCBI Accession	NP_000039.2
KEGG	hsa:435
String	9606.ENSP00000307188
Molecular Weight	Calculated MW: 52 kDa Observed MW: 49 kDa
Buffer	PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Argininosuccinate Lyase (ASL)

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