Aspartate Aminotransferase, Cytoplasmic (GOT1) Antibody

Aspartate Aminotransferase, Cytoplasmic (GOT1) Antibody is a Rabbit Polyclonal antibody for the detection of GOT1.

Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H (2) S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain.

Target	Aspartate Aminotransferase, Cytoplasmic (GOT1)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	ELISA, WB, IHC, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IHC: 1/50 - 1/200, IF/ICC: 1/10 - 1/100. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	glutamic-oxaloacetic transaminase 1, soluble(aspartate aminotransferase 1)
Isotype	IgG
Form	Liquid
Purity	≥ 95% (SDS-PAGE)
Purification	Purified by immunogen affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Validity	12 months.
UniProt Primary AC	P17174 (UniProt, ExPASy)
UniProt Secondary AC	B2R6R7, B7Z7E9, Q5VW80
UniProt Entry Name	AATC_HUMAN
Gene Symbol	GOT1
GeneID	2805
KEGG	hsa:2805
String	9606.ENSP00000359539
Molecular Weight	Observed MW: 43-46 kDa
Buffer	PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Concentration	2 mg/ml
Availability	Shipped within 5-12 working days.
Note	This product is for research use only.

Research Articles on Aspartate Aminotransferase, Cytoplasmic (GOT1)

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