Cyclic AMP-Dependent Transcription Factor ATF-3 (ATF3) Antibody
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Catalogue No: abx028913
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(Size: 80 µl)
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Datasheet SDS
Cyclic AMP-Dependent Transcription Factor ATF-3 is a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. Multiple transcript variants encoding two different isoforms have been found for this gene. The longer isoform represses rather than activates transcription from promoters with ATF binding elements. The shorter isoform (deltaZip2) lacks the leucine zipper protein-dimerization motif and does not bind to DNA, and it stimulates transcription presumably by sequestering inhibitory co-factors away from the promoter. It is possible that alternative splicing of the ATF3 gene may be physiologically important in the regulation of target genes.
Research Articles on Cyclic AMP-Dependent Transcription Factor ATF-3 (ATF3)
| Target | Cyclic AMP-Dependent Transcription Factor ATF-3 (ATF3) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, FCM |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, FCM: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 140-168 amino acids from the C-terminal region of human ATF3. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P18847 (UniProt, ExPASy) |
| UniProt Secondary AC | Q5VTZ2, Q6ICQ9, Q7Z566, Q8WYM6 |
| UniProt Entry Name | ATF3_HUMAN |
| Gene Symbol | ATF3 |
| GeneID | 467 |
| OMIM | 603148 |
| NCBI Accession | NP_001025458.1 NM_001030287.3 |
| HGNC | 785 |
| KEGG | hsa:467 |
| Ensembl | ENSG00000162772 |
| String | 9606.ENSP00000344352 |
| Molecular Weight | Calculated MW: 20.6 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse, Rat and Cow ATF3. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |