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Cyclic AMP-Dependent Transcription Factor ATF-4 (ATF4) Antibody

Catalogue No: abx000590
Price: £120.00
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ATF4 Antibody is a Rabbit Polyclonal antibody against ATF4. ATF4 is a transcription factor, that accumulates predominantly in osteoblasts, where it regulates terminal osteoblast differentiation and bone formation. As a basic leucine-zipper (bZip) transcription factor, ATF4 can regulate amino acid metabolism, cellular redox state, and anti-stress responses. It also regulates age-related and diet-induced obesity and glucose homeostasis in mammals, and has conserved metabolic functions in flies. Due to its location at chromosome 22q13, a region linked to schizophrenia, ATF4 is considered as a positional candidate gene for schizophrenia. Otherwise, since ATF4 is induced by tumour microenvironmental factors, and regulates processes relevant to cancer progression, it might serve as a potential therapeutic target in cancer. This antibody is a rabbit polyclonal antibody raised against full length human ATF4 antigen.

Target ATF4
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human ATF4.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P18848 (UniProt, ExPASy)
UniProt Secondary AC Q96AQ3, Q9UH31
Gene Symbol ATF4
GeneID 468
KEGG hsa:46
String 9606.ENSP00000336790
Molecular Weight Calculated MW: 38 kDa
Observed MW: 37 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration 1.67 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Cyclic AMP-Dependent Transcription Factor ATF-4 (ATF4) Antibody

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