Cyclic AMP-Dependent Transcription Factor ATF-6 Alpha (ATF6) Antibody
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Catalogue No: abx000591
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US$217.50
(Size: 20 µl)
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Datasheet SDS
ATF6 Antibody is a Rabbit Polyclonal antibody against ATF6. This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis.
Research Articles on Cyclic AMP-Dependent Transcription Factor ATF-6 Alpha (ATF6)
| Target | Cyclic AMP-Dependent Transcription Factor ATF-6 Alpha (ATF6) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant protein corresponding to ATF6. The exact sequence is proprietary. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P18850 (UniProt, ExPASy) |
| UniProt Secondary AC | O15139, Q5VW62, Q6IPB5, Q9UEC9 |
| UniProt Entry Name | ATF6A_HUMAN |
| Gene Symbol | ATF6 |
| GeneID | 22926 |
| NCBI Accession | NP_031374.2 |
| KEGG | hsa:22926 |
| String | 9606.ENSP00000356919 |
| Molecular Weight | Calculated MW: 75 kDa Observed MW: 90-100 kDa |
| Buffer | PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol. |
| Concentration | 1.67 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |