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Cyclic AMP-Dependent Transcription Factor ATF-6 Alpha (ATF6) Antibody

Catalogue No: abx000591
Price: £120.00
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ATF6 Antibody is a Rabbit Polyclonal antibody against ATF6. This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis.

Target ATF6
Clonality Polyclonal
Reactivity Human, Mouse
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Synthetic peptide. C term -peptide of human ATF6.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P18850 (UniProt, ExPASy)
UniProt Secondary AC O15139, Q5VW62, Q6IPB5, Q9UEC9
UniProt Entry Name ATF6A_HUMAN
Gene Symbol ATF6
GeneID 22926
String 9606.ENSP00000356919
Molecular Weight Calculated MW: 74 kDa
Observed MW: 80 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration 1.67 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Cyclic AMP-Dependent Transcription Factor ATF-6 Alpha (ATF6) Antibody

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