Ubiquitin-Like-Conjugating Enzyme ATG3 (ATG3) Antibody

Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). APG3L is an E2-like conjugating enzyme facilitating covalent binding of APG8 (MAP1LC3) to phosphatidylethanolamine (PE). APG7 (an E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with APG3. Formation of the PE conjugate is essential for autophagy.

Target	Ubiquitin-Like-Conjugating Enzyme ATG3 (ATG3)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 168-197 amino acids from the C-terminal region of human ATG3.
Isotype	IgG
Form	Liquid
Purification	Purified Rabbit Polyclonal Antibody.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q9NT62 (UniProt, ExPASy)
UniProt Secondary AC	Q6PKC5, Q9H6L9
UniProt Entry Name	ATG3_HUMAN
Gene Symbol	ATG3
GeneID	64422
OMIM	609606
NCBI Accession	NP_001265641.1 NP_071933.2
HGNC	20962
KEGG	hsa:64422
Ensembl	ENSG00000144848
String	9606.ENSP00000283290
Molecular Weight	Calculated MW: 35.9 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Cow ATG3.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Ubiquitin-Like-Conjugating Enzyme ATG3 (ATG3)

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