Serine-Protein Kinase ATM (ATM) Antibody
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Catalogue No: abx011708
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US$427.75
(Size: 100 µl)
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Datasheet SDS
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. At least three alternatively spliced transcript variants, which encode distinct isoforms, have been identified.
Research Articles on Serine-Protein Kinase ATM (ATM)
| Target | Serine-Protein Kinase ATM (ATM) |
| Research Area | Signal Transduction, Tumor Immunity, Neuroscience, Cancer |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of human ATM expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q13315 (UniProt, ExPASy) |
| UniProt Secondary AC | B2RNX5, O15429, Q12758, Q16551, Q93007, Q9NP02, Q9UCX7 |
| UniProt Entry Name | ATM_HUMAN |
| Gene Symbol | ATM |
| GeneID | 472 |
| OMIM | 208900 |
| HGNC | 795 |
| KEGG | hsa:472 |
| Ensembl | ENSG00000149311 |
| String | 9606.ENSP00000278616 |
| Molecular Weight | 351 kDa |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | Not determined. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |