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Serine-Protein Kinase ATM (ATM) Antibody
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Catalogue No: abx004526
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US$348.00
(Size: 60 µl)
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Datasheet SDS
ATM Antibody is a Rabbit Polyclonal antibody against ATM. The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.
Research Articles on Serine-Protein Kinase ATM (ATM)
| Target | Serine-Protein Kinase ATM (ATM) |
| Research Area | Signal Transduction, Tumor Immunity, Neuroscience, Cancer |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | A synthetic peptide corresponding to human ATM |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q13315 (UniProt, ExPASy) |
| UniProt Secondary AC | B2RNX5, O15429, Q12758, Q16551, Q93007, Q9NP02, Q9UCX7 |
| UniProt Entry Name | ATM_HUMAN |
| Gene Symbol | ATM |
| GeneID | 472 |
| NCBI Accession | NP_000042.3 |
| KEGG | hsa:472 |
| String | 9606.ENSP00000278616 |
| Molecular Weight | Calculated MW: 350 kDa Observed MW: 310 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
