ATM (pS1981) Antibody
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Catalogue No: abx032012
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US$326.25
(Size: 80 µl)
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Datasheet SDS
ATM belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. ATM and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in the gene encoding ATM are associated with ataxia telangiectasia, an autosomal recessive disorder.
Research Articles on ATM (pS1981)
| Target | ATM (pS1981) |
| Clonality | Polyclonal |
| Target Modification | Ser1981 |
| Modification | Phosphorylation |
| Reactivity | Human |
| Tested Applications | ELISA, IF/ICC, DB |
| Host | Rabbit |
| Recommended dilutions | IF/ICC: 1/10 - 1/50, DB: 1/500. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1981 of human ATM. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by two-step phosphospecific peptide affinity purification. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q13315 (UniProt, ExPASy) |
| UniProt Secondary AC | B2RNX5, O15429, Q12758, Q16551, Q93007, Q9NP02, Q9UCX7 |
| UniProt Entry Name | ATM_HUMAN |
| KEGG | hsa:472 |
| String | 9606.ENSP00000278616 |
| Molecular Weight | Calculated MW: 351 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |